Academic Articles
The following is a chronological list of all of the articles we have been able to find about FOXP1. If you find an article that you think would be useful for us to share here, please contact us at info@foxp1.org
2022
August
Case report: FOXP1 syndrome caused by a de novo splicing variant (c.1652+5 G>A) of the FOXP1 gene
Min Chen, 1 Yixi Sun, 1 Yeqing Qian, 1 Na Chen, 1 Hongge Li, 1 Liya Wang, 1 and Minyue Dongcorresponding
2021
December
Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD) With Language Impairment Accompanied by Developmental Disability Caused by Forkhead Box Protein 1 (FOXP1) Exon Deletion: A Case Report
Shuliweeh Alenezi, Ahmed Alyahya, Hesham Aldhalaan
2021
September
Individuals with FOXP1 syndrome present with a complex neurobehavioral profile with high rates of ADHD, anxiety, repetitive behaviors, and sensory symptoms
M. Pilar Trelles, Tess Levy, Bonnie Lerman, Paige Siper, Reymundo Lozano, Danielle Halpern, Hannah Walker, Jessica Zweifach, Yitzchak Frank, Jennifer Foss-Feig, Alexander Kolevzon & Joseph Buxbaum
2021
May
Severe speech impairment is a distinguishing feature of FOXP1-related disorder
Ruth O Braden, David J Amori, Simon E Fisher, Cristina Mei,
Candace T Muers, Heather Mefford, DeepakGill, Siddharth Srivastava,
Lindsay C Swanson, Himanshu Goel, Ingrid E Scheffer, Angela T Morgan
2021
April
FOXP1 syndrome: a review of the literature and practice parameters for medical assessment and monitoring
Reymundo Lozano, Catherine Gbekie, Paige M. Siper, Shubhika Srivastava, Jeffrey M. Saland, Swathi Sethuram, Lara Tang, Elodie Drapeau, Yitzchak Frank, Joseph D. Buxbaum & Alexander Kolevzon
2021
March
A genome-wide association study identifies a gene network associated with paranoid schizophrenia and antipsychotics-induced tardive dyskinesia
Anastasia Levchenko 1, Alexander Kanapin 2, Anastasia Samsonova 2, Olga Yu Fedorenko 3, Elena G Kornetova 4, Timur Nurgaliev 5, Galina E Mazo 6, Arkadiy V Semke 7, Alexander O Kibitov 8, Nikolay A Bokhan 9, Raul R Gainetdinov 10, Svetlana A Ivanova 11
2021
February
Autism-linked gene FoxP1 selectively regulates the cultural transmission of learned vocalizations
F Garcia-Oscos 1, T M I Koch 1, H Pancholi 1, M Trusel 1, V Daliparthi 1, M Co 1, S E Park 1, F Ayhan 1, D H Alam 1, J E Holdway 1, G Konopka 1, T F Roberts 2
2021
February
Ensemble Switching of the DNA-Binding Domain of Human FOXP1
Narendar Kolimi, Exequiel Medina, Cesar Ramirez-Sarmiento, Hugo Sanabria, Jorge Babul
2021
January
FOXP1 negatively regulates intrinsic excitability in D2 striatal projection neurons by promoting inwardly rectifying and leak potassium currents
Nitin Khandelwal 1, Sheridan Cavalier 1, Volodymyr Rybalchenko 1, Ashwinikumar Kulkarni 1, Ashley G Anderson 1, Genevieve Konopka 2, Jay R Gibson 3
2021
January
FOXP1 Interacts with MyoD to Repress its Transcription and Myoblast Conversion
Woodring E Wright 1, Chuan Li 2, Chang-Xue Zheng 3, Haley O Tucker 3
2020
December
Coupling of autism genes to tissue-wide expression and dysfunction of synapse, calcium signaling and transcriptional regulation
Jamie Reilly, Louise Gallagher, Geraldine Leader, Sanbing Shen
2020
December
Identification of FoxP circuits involved in locomotion and object fixation in Drosophila
Ottavia Palazzo 1, Mathias Rass 1, Björn Brembs 1
2020
November
Dysfunction of the corticostriatal pathway in autism spectrum disorders Wei Li 1, Lucas Pozzo-Miller 1
2020
October
Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations
Dervla M Connaughton et al.
2020
September
Peruvian Newborn Male with 3p13 Deletion Syndrome Encompassing the FOXP1 Gene: Review of the Literature
Hugo H. Abarca-Barriga
2020
September
Intrinsically Disordered Regions of the DNA-Binding Domain of Human FoxP1 Facilitate Domain Swapping
ExequielMedina1PabloVillalobos1George L.Hamilton2ElizabethA.Komives3HugoSanabria2César A.Ramírez-Sarmiento45JorgeBabul1
2020
September
FOXP transcription factors in vertebrate brain development, function, and disorders
Marissa Co 1, Ashley G Anderson 2, Genevieve Konopka 2
2020
March
Single-Cell Analysis of Foxp1-Driven Mechanisms Essential for Striatal Development
Ashley G Anderson 1, Ashwinikumar Kulkarni 1, Matthew Harper 1, Genevieve Konopka
2020
February
Foxp1 Regulates Neural Stem Cell Self-Renewal and Bias Toward Deep Layer Cortical Fates
Caroline Alayne Pearson 1, Destaye M Moore 1, Haley O Tucker 2, Joseph D Dekker 2, Hui Hu 3, Amaya Miquelajáuregui 4, Bennett G Novitch 5
2020
January
FOXP transcription factors in vertebrate brain development, function, and disorders
Marissa Co Ashley G. Anderson Genevieve Konopka
2019
December
Differential Song Deficits after Lentivirus-Mediated Knockdown of FoxP1, FoxP2, or FoxP4 in Area X of Juvenile Zebra Finches
Philipp Norton 1, Peggy Barschke 1, Constance Scharff 1, Ezequiel Mendoza 2
2019
October
Gastrointestinal dysfunction in autism displayed by altered motility and achalasia in Foxp1 +/- mice
Henning Fröhlich 1, Marie Luise Kollmeyer 1, Valerie Catherine Linz 1, Manuel Stuhlinger 1, Dieter Groneberg 2, Amelie Reigl 2, Eugen Zizer 3, Andreas Friebe 2, Beate Niesler 1 4, Gudrun Rappold 5
2019
July
Identification of a de novo FOXP1 mutation and incidental discovery of inherited genetic variants contributing to a case of autism spectrum disorder and epilepsy
Kristy Jay 1, Amit Mitra 2, Taylor Harding 1, David Matthes 3, Brian Van Ness 1
2019
July
An Autism-Related, Nonsense Foxp1 Mutant Induces Autophagy and Delays Radial Migration of the Cortical Neurons
Xue Li 1 2 3, Xin Han 1 2 3, Xiaomeng Tu 1 2 3, Dan Zhu 1 2 3, Yue Feng 1 2 3, Tian Jiang 4, Youping Yang 4, Jia Qu 1 2 3, Jie-Guang Chen 1 2 3
2019
March
Regulatory genes and pathways disrupted in autism spectrum disorders
Fatma Ayhan 1, Genevieve Konopka 2
2019
February
Conserved regulation of neurodevelopmental processes and behavior by FoxP in Drosophila
Anna Castells-Nobau 1, Ilse Eidhof 1, Michaela Fenckova 1, Dova B Brenman Suttner 2, Jolanda M Scheffer-de Gooyert 1, Sheren Christine 1, Rosa L Schellevis 1, Kiran van der Laan 1, Christine Quentin 3 4, Lisa van Ninhuijs 1, Falko Hofmann 1, Radoslaw Ejsmont 5, Simon E Fisher 6 7, Jamie M Kramer 1, Stephan J Sigrist 3 4, Anne F Simon 2, Annette Schenck 1
2018
December
An Autism-Related, Nonsense Foxp1 Mutant Induces Autophagy and Delays Radial Migration of the Cortical Neurons
Urreizti, R., Damanti, S., Esteve, C. et al
2018
November
Characterization of a recurrent missense mutation in the forkhead DNA binding domain of FOXP1
Tyler B Johnson 1, Keegan Mechels 1, Ruthellen H Anderson 1, Jacob T Cain 1, David A Sturdevant 1, Stephen Braddock 2, Hailey Pinz 2, Mark A Wilson 3, Megan Landsverk 4, Kyle J Roux 5 6, Jill M Weimer 7 8
2018
October
Whole genome sequencing identifies a de novo 2.1 Mb balanced paracentric inversion disrupting FOXP1 and leading to severe intellectual disability
M-L Vuillaume 1, B Cogné 2, M Jeanne 1, A Boland 3, D-C Ung 4, D Quinquis 5, T Besnard 5, J-F Deleuze 3, R Redon 6, S Bézieau 2, F Laumonnier 1, A Toutain 7
2018
September
Differential and Overlapping Pattern of Foxp1 and Foxp2 Expression in the Striatum of Adult Mouse Brain
Weng Lam Fong 1, Hsiao-Ying Kuo 1, Hsiao-Lin Wu 1, Shih-Yun Chen 1, Fu-Chin Liu 2
2018
March
FOXP1-related intellectual disability syndrome: a recognizable entity
Ilse Meerschaut , Daniel Rochefort, Nicole Revençu, Justine Pètre, Christina Corsello,Guy A Rouleau (2017)
2018
January
A De Novo FOXP1 Truncating Mutation in a Patient Originally Diagnosed as C Syndrome
Roser Urreizti 1, Sarah Damanti 2 3, Carla Esteve 4, Héctor Franco-Valls 4, Laura Castilla Vallmanya 4, Raul Tonda 5 6, Bru Cormand 4, Lluïsa Vilageliu 4, John M Opitz 7, Giovanni Neri 8, Daniel Grinberg 4, Susana Balcells 4
2017
December
FOXP1 haploinsufficiency: Phenotypes beyond behavior and intellectual disability?
Angela Myers 1, Christèle du Souich 2 3, Connie L Yang 4, Lior Borovik 5, Jill Mwenifumbo 3, Rosemarie Rupps 2 3, Causes Study 3, Anna Lehman 2 3, Cornelius F Boerkoel 1 2 3
2017
November
FOXP1-related intellectual disability syndrome: a recognisable entity
Ilse Meerschaut , Daniel Rochefort, Nicole Revençu, Justine Pètre, Christina Corsello,Guy A Rouleau,
2017
November
Foxp1 in Forebrain Pyramidal Neurons Controls Gene Expression Required for Spatial Learning and Synaptic Plasticity
Daniel J Araujo 1, Kazuya Toriumi 1 2, Christine O Escamilla 3, Ashwinikumar Kulkarni 1, Ashley G Anderson 1, Matthew Harper 1, Noriyoshi Usui 1, Jacob Ellegood 4, Jason P Lerch 4 5, Shari G Birnbaum 6, Haley O Tucker 7, Craig M Powell 1 3 6, Genevieve Konopka
2017
November
Equivalent missense variant in the FOXP2 and FOXP1 transcription factors causes distinct neurodevelopmental disorders
Elliot Sollis 1, Pelagia Deriziotis 1, Hirotomo Saitsu 2, Noriko Miyake 3, Naomichi Matsumoto 3, Mariëtte J V Hoffer 4, Claudia A L Ruivenkamp 4, Mariëlle Alders 5, Nobuhiko Okamoto 6, Emilia K Bijlsma 4, Astrid S Plomp 5, Simon E Fisher 1 7
2017
November
FOXP1 Promotes Embryonic Neural Stem Cell Differentiation by Repressing Jagged1 Expression
Luca Braccioli 1, Stephin J Vervoort 2, Youri Adolfs 3, Cobi J Heijnen 4, Onur Basak 5, R Jeroen Pasterkamp 3, Cora H Nijboer 6, Paul J Coffer 7
2017
October
Foxp1 regulation of neonatal vocalizations via cortical development
Noriyoshi Usui 1 2 3, Daniel J Araujo 1, Ashwinikumar Kulkarni 1, Marissa Co 1, Jacob Ellegood 4, Matthew Harper 1, Kazuya Toriumi 1 5, Jason P Lerch 4 6, Genevieve Konopka 1
2017
October
Prospective investigation of FOXP1 syndrome
Paige M Siper # 1 2, Silvia De Rubeis # 1 2, Maria Del Pilar Trelles 1 2, Allison Durkin 1 2, Daniele Di Marino 3, François Muratet 1 2, Yitzchak Frank 1 2, Reymundo Lozano 4 2, Evan E Eichler 5, Morgan Kelly 6, Jennifer Beighley 6, Jennifer Gerdts 6, Arianne S Wallace 6, Heather C Mefford 6, Raphael A Bernier 6, Alexander Kolevzon # 7 2, Joseph D Buxbaum
2017
April
Foxp1 expression is essential for sex-specific murine neonatal ultrasonic vocalization
Henning Fröhlich 1, Rafiullah Rafiullah 1, Nathalie Schmitt 1, Sonja Abele 1, Gudrun A Rappold 1 2
2017
April
SUMOylation of FOXP1 regulates transcriptional repression via CtBP1 to drive dendritic morphogenesis
Daniel L Rocca 1, Kevin A Wilkinson 1, Jeremy M Henley
2016
August
FoxP1 marks medium spiny neurons from precursors to maturity and is required for their differentiation
S V Precious 1, C M Kelly 1, A E Reddington 1, N N Vinh 1, R C Stickland 1, V Pekarik 2, C Scherf 3, R Jeyasingham 1, J Glasbey 1, M Holeiter 1, L Jones 4, M V Taylor 5, A E Rosser 6
2016
July
The RNA binding protein HuR determines the differential translation of autism-associated FoxP subfamily members in the developing neocortex
T Popovitchenko 1, K Thompson 1, B Viljetic 1, X Jiao 2, D L Kontonyiannis 3, M Kiledjian 2, R P Hart 2, M R Rasin 1
2016
March
Expression of forkhead box transcription factorgenes Foxp1 and Foxp2 during jaw development
Jeffry M.CesarioaAsma A.AlmaidhanbJuheeJeonga
2016
February
Identification and functional characterization of de novo FOXP1 variants provides novel insights into the etiology of neurodevelopmental disorder
Elliot Sollis 1, Sarah A Graham 1, Arianna Vino 1, Henning Froehlich 2, Maaike Vreeburg 3, Danai Dimitropoulou 1, Christian Gilissen 4, Rolph Pfundt 4, Gudrun A Rappold 5, Han G Brunner 6, Pelagia Deriziotis 7, Simon E Fisher 8
2015
October
FoxP1 orchestration of ASD-relevant signaling pathways in the striatum
Daniel J Araujo 1, Ashley G Anderson 1, Stefano Berto 1, Wesley Runnels 1, Matthew Harper 1, Simon Ammanuel 1, Michael A Rieger 2, Hung-Chung Huang 3, Kacey Rajkovich 1, Kristofer W Loerwald 1, Joseph D Dekker 4, Haley O Tucker 4, Joseph D Dougherty 2, Jay R Gibson 1, Genevieve Konopka 1
2015
July
Differential FoxP2 and FoxP1 expression in a vocal learning nucleus of the developing budgerigar
Osceola Whitney 1, Tawni Voyles 1, Erina Hara 1, Qianqian Chen 2, Stephanie A White 2 3, Timothy F Wright 1
2015
May
Brain-specific Foxp1 deletion impairs neuronal development and causes autistic-like behaviour
C Bacon1,2, M Schneider3,7, C Le Magueresse2,4,5,7, H Froehlich1,2, C Sticht6, C Gluch3, H Monyer2,4 and GA Rappold1,2
2015
May
Foxp1 regulates cortical radial migration and neuronal morphogenesis in developing cerebral cortex
Xue Li 1, Jian Xiao 1, Henning Fröhlich 2, Xiaomeng Tu 1, Lianlian Li 1, Yue Xu 1, Huateng Cao 1, Jia Qu 1, Gudrun A Rappold 2, Jie-Guang Chen 1
2015
April
A de novo FOXP1 variant in a patient with autism, intellectual disability and severe speech and language impairment
Reymundo Lozano 1, Arianna Vino 2, Cristina Lozano 1, Simon E Fisher 2 3, Pelagia Deriziotis 2
2015
February
Genetic Changes Shaping the Human Brain
lByoung-IlBae1DivyaJayaraman1Christopher A.Walsh1
2014
July
Clinical phenotype of a patient with FOXP1 deletion
(T. Blanco Sánchez, et al., 2014) Article in Spanish
2013
December
FOXP1 mutations cause intellectual disability and a recognizable phenotype
Anna K Le Fevre 1, Sharelle Taylor, Neva H Malek, Denise Horn, Christopher W Carr, Omar A Abdul-Rahman, Sherindan O'Donnell, Trent Burgess, Marie Shaw, Jozef Gecz, Nicole Bain, Kerry Fagan, Matthew F Hunter
2013
October
Expression analysis of the speech-related genes FoxP1 and FoxP2 and their relation to singing behavior in two songbird species.
Chen Q, Heston JB, Burkett ZD, White SA.
2013
July
Increased gene expression of FOXP1 in patients with autism spectrum disorders
Wei-Hsien Chien 1, Susan Shur-Fen Gau, Chun-Houh Chen, Wen-Che Tsai, Yu-Yu Wu, Po Hsu Chen, Chi-Yung Shang, Chia-Hsiang Chen
2013
March
Genetic Abnormalities in FOXP1 Are Associated with Congenital Heart Defects
(Sheng-Wei Chang, et al., 2013)
2013
March
3p14.1 de novo microdeletion involving the FOXP1 gene in an adult patient with autism, severe speech delay and deficit of motor coordination
Orazio Palumbo 1, Leonardo D'Agruma, Adelaide Franca Minenna, Pietro Palumbo, Raffaella Stallone, Teresa Palladino, Leopoldo Zelante, Massimo Carella
2012
December
3p14.1 de novo microdeletion involving the FOXP1 gene in an adult patient with autism, severe speech delay and deficit of motor coordination
Orazio Palumbo a, Leonardo D'Agruma a, Adelaide Franca Minenna b, Pietro Palumbo a,c, Raffaella Stallone a, Teresa Palladino a, Leopoldo Zelante a, Massimo Carella a,⁎
2012
December
ASD-relevant Animal Models of the Foxp Family of Transcription Factors
J Michael Bowers 1, Genevieve Konopka 1
2012
April
Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries
(Michael E. Talkowski, et al., 2012)
2012
February
The distinct and overlapping phenotypic spectra of FOXP1 and FOXP2 in cognitive disorders
Claire Bacon 1, Gudrun A Rappold
2011
July
Mild to Moderate Intellectual Disability and Significant Speech and Language Deficits in Patients with FOXP1 Deletions and Mutations
Horn D.
2010
November
Identification of FOXP1 deletions in three unrelated patients with mental retardation and significant speech and language deficits
Denise Horn 1, Johannes Kapeller, Núria Rivera-Brugués, Ute Moog, Bettina Lorenz Depiereux, Sebastian Eck, Maja Hempel, Janine Wagenstaller, Alex Gawthrope, Anthony P Monaco, Michael Bonin, Olaf Riess, Eva Wohlleber, Thomas Illig, Connie R Bezzina, Andre Franke, Stephanie Spranger, Pablo Villavicencio-Lorini, Wenke Seifert, Jochen Rosenfeld, Eva Klopocki, Gudrun A Rappold, Tim M Strom
2010
October
De novo mutations in FOXP1 in cases with intellectual disability, autism, and language impairment
Fadi F Hamdan 1, Hussein Daoud, Daniel Rochefort, Amélie Piton, Julie Gauthier, Mathieu Langlois, Gila Foomani, Sylvia Dobrzeniecka, Marie-Odile Krebs, Ridha Joober, Ronald G Lafrenière, Jean-Claude Lacaille, Laurent Mottron, Pierre Drapeau, Miriam H Beauchamp, Michael S Phillips, Eric Fombonne, Guy A Rouleau, Jacques L Michaud
2010
June
Chiari I malformation, delayed gross motor skills, severe speech delay, and epileptiform discharges in a child with FOXP1 haploinsufficiency
Christopher W Carr, Daniel Moreno-De-Luca, Colette Parker, Holly H Zimmerman, Nikki Ledbetter, Christa Lese Martin, William B Dobyns & Omar A Abdul-Rahman
2010
March
The forkhead transcription factors, Foxp1 and Foxp2, identify different subpopulations of projection neurons in the mouse cerebral cortex
T Hisaoka 1, Y Nakamura, E Senba, Y Morikawa
2009
September
A 785kb deletion of 3p14.1p13, including the FOXP1 gene, associated with speech delay, contractures, hypertonia and blepharophimosis
Mitchel J Pariani 1, Andrew Spencer, John M Graham Jr,