Gene Expression

November 2017

Foxp1 in Forebrain Pyramidal Neurons Controls Gene Expression Required for Spatial Learning and Synaptic Plasticity

Daniel J Araujo, Kazuya Toriumi, Christine O Escamilla, Ashwinikumar Kulkarni, Ashley G Anderson, Matthew Harper, Noriyoshi Usui, Jacob Ellegood, Jason P Lerch, Shari G Birnbaum, Haley O Tucker, Craig M Powell, Genevieve Konopka

Mice with FOXP1 removed from the neocortex and hippocampus showed reduced social interaction, hyperactivity, and spatial learning difficulties.

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October 2015

FoxP1 orchestration of ASD-relevant signaling pathways in the striatum

Daniel J Araujo, Ashley G Anderson, Stefano Berto, Wesley Runnels, Matthew Harper, Simon Ammanuel, Michael A Rieger, Hung-Chung Huang, Kacey Rajkovich, Kristofer W Loerwald, Joseph D Dekker, Haley O Tucker, Joseph D Dougherty, Jay R Gibson, Genevieve Konopka

FOXP1 regulates other genes that are known to be implicated in autism, with mutations increasing activity of striatal neurons.

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