Striatum Archives - FOXP1 Foundation

January 2021

FOXP1 negatively regulates intrinsic excitability in D2 striatal projection neurons by promoting inwardly rectifying and leak potassium currents

Nitin Khandelwal, Sheridan Cavalier, Volodymyr Rybalchenko, Ashwinikumar Kulkarni, Ashley G Anderson, Genevieve Konopka, Jay R Gibson

FOXP1 deletion causes hyperexcitability in striatal D2 neurons through potassium channel regulation.

Ion Channels Neurophysiology Neuroscience Striatum

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March 2020

Single-Cell Analysis of Foxp1-Driven Mechanisms Essential for Striatal Development

Ashley G Anderson, Ashwinikumar Kulkarni, Matthew Harper, Genevieve Konopka

Single-cell analysis reveals how FOXP1 regulates striatal structure and dopamine-receiving cell types.

Brain Development Cell Types Neuroscience Striatum

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October 2015

FoxP1 orchestration of ASD-relevant signaling pathways in the striatum

Daniel J Araujo, Ashley G Anderson, Stefano Berto, Wesley Runnels, Matthew Harper, Simon Ammanuel, Michael A Rieger, Hung-Chung Huang, Kacey Rajkovich, Kristofer W Loerwald, Joseph D Dekker, Haley O Tucker, Joseph D Dougherty, Jay R Gibson, Genevieve Konopka

FOXP1 regulates other genes that are known to be implicated in autism, with mutations increasing activity of striatal neurons.

ASD Gene Expression Neuroscience Striatum

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